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2015). These experiments, taken together, propose that, although a immediate activation of GPR55 or PPAR‐α takes place, PEA can develop its anti‐inflammatory motion within the intestine also by way of oblique activation of CB1 and CB2 receptors, most likely due to the ability of this compound to potentiate the action of endocannabinoids at the
2016a). This lesser increase was proportionate into the more compact peak of PEA amounts detected in human volunteers when compared with beagle canines. This variance, consequently, could be due to the decrease overall volume of PEA acutely administered to human volunteers (about ∼five vs. 30 mg·kg−1 in pet dogs) also to the fact that this wa
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